- Identification of molecular determinants of paramyxovirus virulence
- Identification of the mechanisms of paramyxovirus pathogenesis
- Molecular characterization of new and emerging avian paramyxoviruses
- Engineering avian paramyxoviruses as vaccine vectors against animal and human pathogens
- Development of safe and effective vaccines against Newcastle disease using reverse genetics system
Dr. Samal’s research is focused on molecular biology and pathogenesis of two economically important negative-strand RNA viruses, bovine respiratory syncytial virus and Newcastle disease virus. Recently developed reverse genetics techniques are used to manipulate the genome of these viruses and study the role of each gene of these viruses in pathogenesis and virulence. Research is also conducted to engineer these recombinant viruses for use as improved live virus vaccines and use as vaccine vectors to express protective antigens of other pathogens.